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Government officials in Guinea-Bissau have formally rejected a clinical trial that would be run by Danish researchers and funded by the US to look for alleged nonspecific harms from the newborn dose of the hepatitis B vaccine. The vaccine dose is currently recommended globally for all newborns and has been used safely and effectively for decades.
In an email to Ars Technica, one of the trial's lead researchers, Christine Stabell Benn of Bandim Health Project and the University of Southern Denmark, said that Guinea-Bissau's Council of Ministers "formally reaffirmed its non-acceptance of the study on 16 October."
The revelation that the study was formally rejected last week comes after news on Monday that judicial police in Guinea-Bissau raided Bandim Health's offices and seized vaccines. Stabell Benn highlighted that the police search came after the trial was rejected.
Police in Guinea-Bissau raided the offices of Danish researchers on Monday, seizing doses of hepatitis B vaccine intended for a vaccine trial for newborns. International health experts have called the trial "unethical," but anti-vaccine Health Secretary Robert F. Kennedy Jr. has attempted to fund it with US taxpayer dollars.
Under Kennedy, the US Centers for Disease Control and Prevention announced in December that it had awarded the Danish researchers—led by married couple Peter Aaby and Christine Stabell Benn of Bandim Health Project—an unsolicited $1.6 million grant to run the trial. Aaby and Stabell Benn are controversial vaccine researchers who claim vaccines cause overlooked harms. They have been repeatedly praised by Kennedy, but are currently under investigation for alleged scientific misconduct by Danish authorities.
Plans for the trial were halted in January as widespread condemnation erupted over the trial's design, which would potentially expose thousands of newborns in the country to hepatitis B, risking a lifelong infection that can lead to liver cirrhosis, cancer, and premature death. Outrage flared again after a Rolling Stone story earlier this month claimed the CDC set aside another $1.6 million in funding in late September and planned to move forward with the trial.
Outrage has erupted among health experts over news that the Centers for Disease Control and Prevention is still eager to fund a widely condemned vaccine trial that would expose newborns in Guinea-Bissau to hepatitis B, putting them at high risk of a lifelong infection, which can lead to liver cirrhosis, liver cancer, and premature death.
The trial was suspended in January after its unethical design came to light and drew international outcry. Although the trial is still halted, staff of the CDC director's office told the agency's budget office in late September to set aside $1.6 million to fund the trial, according to a report by Rolling Stone. The money was to be pulled from funding for the CDC's global health security programs, which might otherwise go toward efforts like combating the Ebola outbreak currently raging in the Democratic Republic of the Congo.
The Department of Health and Human Services, which oversees the CDC, did not respond to a request for comment from Ars Technica.
Scientists have an indisputable playful side, evidenced by frequent allusions to popular culture in their research publications. That includes popular song lyrics. And the most popular musical group, in terms of how frequently their songs and lyrics appear in the scientific literature, is The Beatles, according to a new paper published in the journal PLoS ONE.
“Some of these are genuinely brilliant," said co-author Gabriel Budel of Delft University of Technology in the Netherlands of the more than 3,000 references they found to The Beatles. "'The lung and winding road' is a paper on Long COVID that changes one vowel. 'Here comes the SU(N)' turns 'Here Comes the Sun' into a quantum computing paper about mathematical groups. Someone was having a very good day at their desk.”
Back in 2014, scientists at the Karolinska Institute in Sweden revealed that they had been deliberately inserting Bob Dylan lyrics into their papers as part of a long-running bet, starting with a 1997 Nature review entitled "Nitric Oxide and inflammation: The answer is blowing in the wind." That resulted in a 2015 study on whether Dylan lyrics appeared elsewhere in the biomedical literature; the most frequently referenced were "The Times They Are A'Changin'" and "Blowing in the Wind."
Vocal fry, aka "creaky voice," is a distinctive drop in pitch, usually at the end of sentences, associated with the speech patterns of young women in particular. Britney Spears is the go-to example of the trend, having famously used it in her 1998 smash hit, "Hit Me Baby (One More Time)," and she's far from the only one.
But what if that popular gender-based stereotype is wrong? Jeanne Brown, a graduate student at McGill University, has found that vocal fry is actually more common in men than women, detailing her experimental findings in a talk at this week's meeting of the Acoustical Society of America in Philadelphia. Per Brown, we perceive it as more prominent in young women.
Vocal fry is the lowest of the human vocal registers, the others being the modal and falsetto registers, as well as the whistle register. It's caused when the vocal cords slacken, leading to irregular vibration and an audible cracking or rattling sound as air is released in spurts. Vocal fry is characterized by very low fundamental frequencies of around 70 Hz. (The lowest end of the range of human hearing is 20 Hz.)
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